Mihály Józsi

Biography

Mihály Józsi is working as a professor at Semmelweis University

Research Interest

Extracellular vesicles are submicron particles secreted by cells in an evolutionally conserved manner and are surrounded by a phospholipid bilayer. Extracellular vesicles (exosomes, microvesicles and apoptotic bodies) may pass blood tissue barriers and may play a significant role in the formation of several diseases. The vesicles entering the extracellular space may interact with the organism’s various cells and molecules, including the so-called complement system. The complement system is the organism’s fundamental defense system, being part of the innate immune system. It has been known for several decades that complement proteins have an important part in the development of several diseases. Our studies aim to answer the following questions. Do certain types of extracellular vesicles activate complements? What type of complement proteins do they bind to? What are the functional consequences of the binding of complement and complement inhibitory proteins to the surface of the extracellular vesicles in case of the formation of inflammatory symptoms? The research group lead by Edit Buzás (Semmelweis University) are in possession of the state-of the-art equipment to study and isolate extracellular vesicles. Combining their methodology and equipment with those of the complement research group lead by Mihály Józsi (Hungarian Academy of Sciences-Eötvös Loránd University) the opportunity of a systematic study of the interaction between complement proteins and extracellular vesicles has been set up.