Department of Biological Sciences
Tata Institute of Fundamental Research
Dr. Shobhona Sharma is a Senior Professor in the Department of Biological Sciences. Her lab is exploring various aspects of biology of the malaria parasite (Plasmodium species) and the host-parasite interactions, during the red blood cell (RBC) stages of the infection. We study acquired immunity to malaria, as well as metabolic changes caused by the infection in the host, through the course of the disease. We also assess flexibility and dynamics of parasite infected RBCs using optical tweezers. In collaboration with ICT, Mumbai, we explore nanolipid carrier-mediated delivery of antimalarials. We have also initiated a study on the effect of mild malaria in the brain of the vertebrate host.
Biology of malarial parasite.
Das S, Rajagopal S, Sivakami S, Sharma S (2012) Erythrocytic stage dependent regulation of oligomerization of Plasmodium ribosomal protein P2. Journal of Biological Chemistry 287:41499.
Das S, Basu H, Sivakami S, Tewari R, Sharma S (2012) Arrest of nuclear division in Plasmodium through blockage of erythrocyte surface exposed ribosomal protein P2. PLOS Pathogens 8:e1002858.
Jain SA, Basu H, Prabhu PS, Soni U, Joshi MD, Mathur D, Patravale VB, Pathak S, Sharma S (2014) Parasite impairment by targeting Plasmodium-infected RBCs using glyceryl-dilaurate nanostructured lipid carriers. Biomaterials 35:6636.