Hifzur Rahman Siddique
Assistant Professor
ZOOLOGY
Aligarh Muslim University
India
Biography
Resistance to therapy severely limits the effectiveness of chemotherapy drugs in treating cancer. For Advanced Cancer, the progression of tumors to the state of chemoresistance, the paucity of knowledge about the mechanism of chemoresistance and lack of therapeutic molecule/s are major stumbling blocks in the management and treatment of disease in cancer patients. Primary or acquired drug resistance remains a fundamental cause of therapeutic failure in cancer therapy. Ever since I have started my research life, I have been trying to understand how different cells, gene, proteins, might contribute to initiation, progression, and Chemoresistance of cancer. Unraveling drug resistance mechanisms and discovery of new therapeutic molecule/s are not only facilitates rational treatment strategies to overcome existing limitations in therapeutic efficacy but will enhance biomarker discovery and the development of companion diagnostics. My laboratory has been investigating the role of cancer stem cells, transcription factor/ stem cell factor, non-coding RNA in the process of primary and acquired chemoresistance using different in vitro models, animal models, and human clinical samples. I have numbers of research articles published in highly reputed international journals. I serve as an editorial Board member and a regular reviewer for different national/international journals. Young investigators who have a strong research interest in Cancer Research and interested to join my Research Group as SERB-NPDF, UGC-Kothari Fellow, CSIR-RA/SRA, Woman Scientist, INSPIRE-DST, etc. are well come to contact at hrsiddique@gmail.com.
Research Interest
Stem cells/ Cancer stem cells, non-coding RNAs, Therapy resistance cancer and Transgenesis
Publications
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Siddique HR, Parray A, Zhong W, et al. 2013. BMI1, Stem Cell Factor Acting as Novel Serum-biomarker for Caucasian and African-American Prostate Cancer. PLoS One 8: e52993. PMID: 23308129. 5-Yr Impact factor- 3.7.
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Siddique HR, Adhami VM, Parray A, et al. 2013. The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NFκB through the RAGE Receptor. Genes & Cancer. 4: 224-234. PMID: 24069509. Impact factor- 5.4.
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Siddique HR, Feldman DE, Chen C, et al. 2015. NUMB Phosphorylation Destabilizes p53 and Promotes Self-renewal of Tumor-Initiating Cells by NANOG-dependent Mechanism in Liver Cancer. Hepatology. 62: 1466-1479. Impact Factor -13.6 PMID: 26174965