J.s Tyagi
Professor
Department of Biotechnology
All India Institute of Medical Sciences
India
Biography
Dr. J.S Tyagi is currently working as Professor and Head at Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi and Honorary Visiting Professor, Translational Health Science and Technology Institute, Faridabad.
Research Interest
Molecular biology, molecular genetics and recombinant DNA technology and Study of Mycobacterium tuberculosis in these areas: Molecular mechanisms of TB pathogenesis with special reference to dormancy Host-pathogen interactions with special reference to dormancy Vitamin C dormancy model DevR-DevS signalling pathway – a novel drug target Development and validation of efficient diagnostic tools for TB
Publications
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Kaur K, Taneja NK, Dhingra S, Tyagi JS (2014) DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase. BMC Microbiology 14:195
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Sikri K, Batra SD, Nandi M, Kumari P, Taneja NK and Tyagi JS (2015) The pleiotropic transcriptional response of Mycobacterium tuberculosis to vitamin C is robust and overlaps with the bacterial response to multiple intracellular stresses. Microbiology 161:739-53
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Vashist A, D. Prithvi Raj, Gupta UD, BhatR, Tyagi JS(2016) The α10 helix of DevR, the Mycobacterium tuberculosis dormancy response regulator, regulates its DNA binding and activity. FEBS Journal doi:10.1111/febs. 13664
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Kaur K*, Priyanka Kumari*, Sharma S, Sehgal S, Tyagi JS (2016) DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis. The FEBS Journal 283, 2949–2962
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Sharma S, Tyagi JS (2016) Mycobacterium tuberculosis DevR/DosR Dormancy Regulator Activation Mechanism: Dispensability of Phosphorylation, Cooperativity and Essentiality of α10 Helix. PLoS ONE 11(8): e0160723. doi:10.1371/journal.pone.0160723
