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Bindhu Paul

Asst. Professor
Nanosciences, Center for Nanosciences
Amrita Institute of Medical Sciences and Research Centre
India

Biography

Dr. Bindhu Paul joined Amrita Centre for Nanosciences and Molecular Medicine as Assistant Professor in January, 2011. Dr. Bindu took M.Sc. in Zoology with specialization in Molecular Genetics and Cytogenetics from Banaras Hindu University, India, and Ph.D. in Population Genetics from Cochin University of Science and Technology. She pursued post-doctoral research in Japan at the National Institute for Basic Biology (National Institute of Natural Sciences). She spent 8 years in Japan doing research in the area of reproductive physiology/endocrinology/developmental biology/toxicology. She has over 18 international publications to her credit. Her research focused on vertebrate sex determination and differentiation and how exposure to endocrine disruptors/synthetic hormones during early development influenced gonadal morphogenesis in Japanese Medaka, which is widely used as a model organism for biomedical research. At Amrita, Dr. Bindu Paul is investigating the interactions between engineered nanoparticles and germ cells, which are responsible for the transmission of genetic material between generations. Other major thrust areas of her research include transgenerational toxicity potential of engineered nanoparticles, developmental origin of adulthood diseases through endocrine disruption, and development of fish models for drug-resistant cancers for screening of molecularly-targeted nanomedicines. A well-established fish facility holding natural as well as transgenic and mutant strains of Japanese Medaka is maintained at Amrita by Dr. Bindu’s team.

Research Interest

Nanosciences

Publications

  • S. Maehiro, Takeuchi, A., Yamashita, J., Hiraki, T., Kawabata, Y., Nakasone, K., Hosono, K., Usami, T., Dr. Bindhu Paul, Nagahama, Y., Oka, Y., and Okubo, K., “Sexually dimorphic expression of the sex chromosome-linked genes cntfa and pdlim3a in the medaka brain”, Biochemical and Biophysical Research Communications, vol. 445, pp. 113 - 119, 2014.

  • S. Narayanan, Dr. Ullas Mony, Vijaykumar, D. K., Dr. Manzoor K., Dr. Bindhu Paul, and Dr. Deepthy Menon, “Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells”, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 11, pp. 1399-1406, 2015.

  • G. J. Pillai, Dr. Bindhu Paul, Shantikumar V Nair, and Dr. Deepthy Menon, “Influence of surface passivation of 2-Methoxyestradiol loaded PLGA nanoparticles on cellular interactions, pharmacokinetics and tumour accumulation.”, Colloids Surf B Biointerfaces, vol. 150, pp. 242-249, 2017.

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