Dr. Geetha Kumar
Professor
School of Biotechnology
Amrita Institute of Medical Sciences and Research Centre
India
Biography
Dr. Kumar obtained her Ph.D from the University of Tennessee, Memphis, USA, where she elucidated the structure-function activity of fadL, a bacterial Long Chain Fatty Acid binding protein. Following her Ph.D, Dr. Kumar did her post-doctoral studies under Dr. Neil Nathanson, at the University of Washington, Seattle, USA, on the regulation of Muscarinic Acetylcholine Receptor (mAChR). She was subsequently associated with Ceptyr Inc., a Biotech company where she worked in the High Throughput Screening (HTS) division that focused on developing drugs against Diabetes. Dr. Kumar is currently an Professor at the School of Biotechnology, Amrita Vishwa Vidyapeetham, where her research focuses on identification and characterization of Natural Product Lead molecules and understanding their role in: Regulating Matrix Metalloproteinases and oncogenic signaling systems and elucidating the molecular mechanisms underlying this process Modulating the complex processes involved in wound healing Pathogenesis and virulence with specific emphasis on Quorum Sensing Cardio-protection to enable their use in combination therapies Regulating Inflammasomes and the inflammatory signaling cascades in disease states Ongoing research interests also include understanding the role played by miRNAs in regulating oncogenesis and exploring the potential of their use independently, or in combination therapies, along with Natural Products.
Research Interest
Cell Biology, Stem Biology, Micro Biology and Biotechnology
Publications
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L. S. Nadler, Dr. Geetha Kumar, Hinds, T. R., Migeon, J. C., and Nathanson, N. M., “Asymmetric distribution of muscarinic acetylcholine receptors in Madin-Darby canine kidney cellsâ€, American Journal of Physiology-Cell Physiology, vol. 277, pp. C1220–C1228, 1999.
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L. S. Nadler, Dr. Geetha Kumar, and Nathanson, N. M., “Identification of a basolateral sorting signal for the M3 muscarinic acetylcholine receptor in Madin-Darby canine kidney cellsâ€, Journal of Biological Chemistry, vol. 276, pp. 10539–10547, 2001.
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Dr. Jyotsna Nambiar, Bose, C., Meera Venugopal, Dr. Asoke Banerji, Patel, T. B., Dr. Geetha Kumar, and Dr. Bipin G. Nair, “Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECKâ€, Experimental Cell Research, vol. 349, pp. 139-151, 2016.