Puspadhwaja Mall

Biography

Manager Company Name Anthem Biosciences Private Limited Dates Employed Apr 2014 – Present Employment Duration 3 yrs 6 mos Location Bengaluru Area, India Research and development Lab Establishment. Complete process development and analytical characterization of Biosimilars ( Proteins, Pegylated Proteins, Peptides and its analogs and Monoclonal Antibodies. Deputy Manager Company Name Anthem Biosciences Private Limited Dates Employed Jun 2013 – Mar 2014 Employment Duration 10 mos Location Bengaluru Area, India Research and development Lab Establishment. Complete process development and analytical characterization of Biosimilars. Process development and Analytical characterization of biosimilars ( proteins, pegylated proteins, peptides and its analogs and monoclonal Antibodies. Research Scientist -I (Assistant Manager) Company Name Cadila Pharmaceuticals Ltd. (Biotech Division) Dates Employed Nov 2011 – Jun 2013 Employment Duration 1 yr 8 mos Location Cadila Pharmaceuticals Limited (Biotech division) Refolding and purification of GCSF. Optimization of physical and chemical parameters for PEGylation and purificaton of Peg-GCSF. Process development for Purification of Antibody. Process development for purification of EPO using affinity and ionexchange chromatography. Purification of polyclonal antibody. Optimization of refolding conditions for bio-therapeutic proteins and enzymes which are expressed in form of inclusion bodies DOE and OFAT based Resin screening. Determination of static and dynamic binding capacity of resins Chromatographic process development for bio-therapeutic proteins to match with innovator by using Ion exchange, HIC, GFC and mixed mode resins. Scale up of process to manufacturing scale from R&D scale. Development of qualified scale down model for all steps Preparation of FMEA and determination of risk Process characterization. Determination of normal operating range, manufacturing operating range and Failure range using DOE Process optimization for monoclonal antibody purification: Harvest clarification Purification process development using protein A with higher recovery percentage

Research Interest

Pharmaceutical science