Dr. Ramaprasad T.r
Scientist
Biochemistry
Central Food Technological Research Institute
India
Biography
Dr. Ramaprasad T.R is currently a Scientist in the department of Biochemistry Central Food Technological Research Institute, India. He completed B.Sc in Biochemistry, Botany, Microbiology University of Mysore, M.Sc in Biotechnology University of Bangalore and PhD in Biochemistry University of Mysore.
Research Interest
Research on dietary implications of fatty acids have reached conclusive stage with clear knowledge from which now dieticians may be able to formulate specific fat based diet for desired effect. However, due to versatility of dietary oils and fats available in nature and also type of bioactive minor components that are embedded make them unique in terms of its physiological effects. Many times, the biochemical parameters that are crucial to be regulated to counter life style diseases are significantly modulated by minor components rather than the fatty acids itself. In my laboratory, we are currently working on elucidating the synergy that may exist between the active minor components of dietary oils with major fatty acids in terms of regulating the complications of diseases mainly arthritis and dyslipidemia. Though arthritis, a major degenerative inflammatory diseases can be controlled with anti-inflammatory drugs, the damage done by it are permanent and cause life-time disability. Similarly, dyslipidemia harmfully modulate the risk factors including cholesterol homeostasis and there by glycemic control. In addition, maternal dyslipidemia may cause a long lasting effect on developing foetus during pregnancy and hence result in metabolic mis-programming leading to future complications during childhood. My group is working on understanding the mechanisms (lipid inflammatory mediated gene regulation) in the above mentioned complications in experimental animal models.
Publications
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Breetha R, Sadashivaiah B, Ramaprasad TR. Dietary omega-3 but not omega-6 fatty acids downregulate maternal dyslipidemia induced oxidative stress: A three generation study in rats. Biochemical and Biophysical Research Communications. 2016: 477, 887-894.
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Nayana V Yadav, Sadashivaiah, Breetha R, Pooja A, Lokesh BR and Ramaprasad TR. Sesame oil and rice bran oil ameliorates adjuvant-induced arthritis in rats: Distinguishing the role of minor components and fatty acids. Lipids. 2016: 51(12), 1385-1395
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Poorna Chandra Rao Y, Sugasini D, Ramaprasad TR and Lokesh BR. Minor Constituents in Rice Bran Oil and Sesame Oil Play a Significant Role in Modulating Lipid Homeostasis and Inflammatory Markers in Rats. J Med Food. 2017: 20 (7), 1–11