Dr. Mahesh Kulharia

Biography

Dr. Mahesh Kulharia Assistant Professor Centre for Computational Sciences School of Basic and Applied Sciences Central University of Punjab 

Research Interest

 The objective of my research group is to understand more about how molecules communicate at atomic level, with a specific focus on proteins, membranes, nucleic acids and small molecules. We explore how proteins interact with the myriad of molecules by analysing the structural data from the PDB, the literature and developing novel algorithms and software tools, which allow us to characterise interaction modes and mechanisms and navigate the interaction and non-interaction space. We investigate the conformational changes these proteins undergo during such interactions to discover how they subtle changes can lead to evolution of new mechanisms and specificities. The pragmatic goal of this research is to move from genotype to phenotype in silico. In parallel, we focus on the modulating the protein behaviour with small molecule / peptide so as to understand and control pathogenic states (for instance: thrombosis, stroke, and even some communicable diseases like tuberculosis).