Dr. Chandi C. Mandal

Biography

Dr. Chandi C. Mandal Associate Professor and Head Department of Biochemistry Central University of Rajasthan  Dr. Mandal’s research interest is aimed at understanding the cellular signal transduction mechanisms involved in breast cancer, bone metastasis and vascular calcification using molecular and cellular biology techniques and animal model systems. Cancer incidence risk is enormously high in all over the world but deaths related to cancer are rapidly increasing in developing countries like India. Advanced techniques are skilled to detect cancers in early stages. Moreover, modern treatment strategies are now quite efficient to extend the life span of cancer patients by taking care primary tumors. It is the fact that almost 80% of cancer patients die mainly due to its metastatic growth in distant organs. The occurrence of metastasis incidence is also increasing due to improve results of primary tumor treatment strategy. Very limited drugs are available in prevention of metastasis-related death although success level is very small. Thus it becomes a deadly threat to cancer patients once primary tumor cells have metastasized to distant sites. Risk of cancer incidence has been linked with different diseases including diabetes, hypercholesterolemia and obesity. Moreover, treatment of cancer patients with chemotherapies, radiation therapies often show deleterious side effects. Therefore, there is an urgent need for improved understanding of the molecular biology of these diseases and development of more selective and targeted pharmacologic therapeutics.

Research Interest

 Dr. Mandal presently focuses his research area on i) finding the molecular mechanism involved in diabetes-associated cancer risk ii) prevention of chemotherapeutic drug-induced systemic toxicity, iii) finding the molecular pathways involved in diabetes-driven vascular calcification.