Ghanshyam Swarup
Professor
Molecular Biology
Centre for Cellular and Molecular Biology
India
Biography
Ghanshyam Swarup (born 1953) is an Indian molecular biologist, a J. C. Bose National Fellow and the head of the Ghanshyam Swarup Research Group of the Centre for Cellular and Molecular Biology. He is known for his studies on glaucoma and the discovery of protein tyrosine phosphatase, a new protein influencing the regulation of cell proliferation. He is an elected fellow of the Indian Academy of Sciences, the Indian National Science Academy and the National Academy of Sciences, India. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1996, for his contributions to biological sciences.
Research Interest
The central theme of Dr. Ghanshyam Swarup group`s research is to understand the function of the protein optineurin and to study the functional defects caused by disease-associated mutations in optineurin. Mutations in the coding region of the gene OPTN, which codes for the protein optineurin, cause glaucoma and ALS (amyotrophic lateral sclerosis).
Publications
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V. Vaibhava, A. Nagabhushana, M.L.S. Chalasani, C. Sudhakar, A. Kumari and G. Swarup (2012). Optineurin mediates negative regulation of Rab8 by the GTPase activating protein TBC1D17. J. Cell Science 125, 5026-5039.
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Sirohi K, Chalasani ML, Sudhakar C, Kumari A, Radha V, Swarup G. (2013) M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. Autophagy 9:4, 510-527.
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Sirohi K, Swarup G. (2016) Defects in autophagy caused by glaucoma-associated mutations in optineurin. Exp Eye Res.144, 54-63.
