Mukesh Lodha
Ramalingaswami Fellow
Molecular Biology
Centre for Cellular and Molecular Biology
India
Biography
Mukesh Lodha is the Ramalingaswami Fellow in Centre for Cellular & Molecular Biology
Research Interest
Barbara McClintock discovered transposable elements in maize. She also realized that transposons inserted near pigmentation or amylose production genes can alter the `state of gene`. What she called `state of gene` is now called `Epigenetic regulation`. Epigenetic information is heritable during mitotic and/meiotic cell divisions but it is not encoded in the genetic material. It is stable even in the absence of initial trigger and is reversible to various extents. Epigenetic regulation is important for heterochromatin maintenance and euchromatic gene regulation among many other cellular processes. One of the important questions in the field of epigenetics is the mechanism of inheritance of epigenetic state.
Publications
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Lodha M, Schulz-Raffelt*. Schroda M. A new assay for promoter analysis in Chlamydomonas reveals roles for heat shock elements and the TATA box in HSP70A promoter-mediated activation of transgene expression. Eukaryotic Cell. 7(1):172-6 (2008).
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Lodha M, Schroda M. Analysis of chromatin structure in the control regions of the chlamydomonas HSP70A and RBCS2 genes. Plant Mol Biol. 59(3):501-13 (2005).
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Lodha M, Marco CF, and Timmermans MCP. The ASYMMETRIC LEAVES Complex Maintains Repression of KNOX Homeobox Genes via Direct Recruitment of Polycomb Complex2. Genes and Development 27(6):596-601 (2013).
