Puran Singh Sijwali
Professor
Molecular Biology
Centre for Cellular and Molecular Biology
India
Biography
Puran Sijwali of Centre for Cellular and Molecular Biology, Hyderabad with expertise in Molecular Biology.
Research Interest
Dr. Sijwali’s lab is working on proteases and virulence proteins of malaria parasites to identify novel antimalarial drug targets and to understand the pathogenesis of lethal Plasmodium falciparum malaria, respectively. On proteases, we are focusing on proteases required for haemoglobin degradation, processing of host and parasite proteins, and anti-oxidative defense.
Publications
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Shenai BR., Sijwali PS., Singh A., and Rosenthal PJ. (2000) Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. Journal of Biological Chemistry 275(37): 29000-29010.
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Sijwali PS., Kato K., Seydel KB., Gut J., Lehman J., Klemba M., Goldberg DE., Miller LH., and Rosenthal PJ. (2004) Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proceedings of the National Academy of Sciences USA 101(23): 8721-8726. Equal Contribution. 3. Sijwali PS. and Rosenthal PJ. (2004) Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proceedings of the National Academy of Sciences USA 101(13): 4384-4389.
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Sijwali PS., Koo J., Singh N., and Rosenthal PJ. (2006) Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol 150(1): 96:106.
