R Nagaraj
J C Bose Fellow
Molecular Biology
Centre for Cellular and Molecular Biology
India
Biography
Ramakrishnan Nagaraj (born 1953) is an Indian biochemist, molecular biologist and the leader of a team of scientists working in the field of peptide biochemistry at Centre for Cellular and Molecular Biology (CCMB). He is known for his studies on hemolytic and antibacterial properties in synthetic analogs of bacterial toxins.
Research Interest
Research has been directed towards structure-function correlations in antibacterial peptides with the objectives of (i) delineating regions that could be important for activity and (ii) designing peptides ~15 residues or less that would have selective antimicrobial activity.
Publications
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Sowmya, B. L., Jagannadham, M. V., and Nagaraj, R. (2006) Interaction of synthetic peptides corresponding to the scaffolding domain of Caveolin-3 with model membranes. Biopolymers 84, 615-624.
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Pallavi, B., and Nagaraj, R. (2003) Palmitoylated peptides from the cysteine- rich domain of SNAP-23 cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation. J Biol Chem 278, 12737-12744.
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Sitaram, N., and Nagaraj, R. (1999) Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Biochim Biophys Acta 1462, 29-54.Mandal, M., Jagannadham, M. V., and Nagaraj, R. (2002) Antibacterial activities and conformations of bovine beta-defensin BNBD-12 and analogs:structural and disulfide bridge requirements for activity. Peptides 23, 413-418.
