Rajan Sankaranarayanan
Chief Scientist
Structural Biology
Centre for Cellular and Molecular Biology
India
Biography
Dr. Rajan Sankaranarayanan is an Indian biologist. He was born in Madras. He holds a position at the Centre for Cellular and Molecular Biology in Hyderabad.
Research Interest
Dr. Rajan's laboratory is interested in exploring the mechanistic basis and functional relevance of unique proofreading mechanisms that are operational in the cell to maintain a high fidelity during translation of the genetic code. We are particularly interested in a D-aminoacyl-tRNA deacylase(DTD)-fold present in two functional contexts a) as an editing module of archaeal threonyl-tRNA synthetases and b) as a free standing domain responsible for 'Chiral proofreading' i.e removal of D-amino acids mistakenly attached to tRNA.
Publications
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Ahmad, et al. (2015) Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme. Nature Commun. 6:7552, : 10.1038/ncomms8552.
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Pawar, K.I., et al. (2017) Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS. elife doi: 10.7554 eLife.24001.
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Routh, S. B., et al. (2016) Elongation factor Tu prevents misediting of Gly-tRNA(Gly) caused by the design behind the chiral proofreading site of D-aminoacyl-tRNA deacylase. PLOS Biol. 14(5) e1002465, 1-22.
