Dr. Asif Ali
Senior Scientist
Natural Product Chemistry
Council of Scientific and Industrial Research (CSIR)
India
Biography
He is a Senior Scientist at the CSIR(Council of Scientific & Industrial Research)-Indian Institute of Integrative Medicine, India.
Research Interest
Total synthesis of antigenic Glycolipids: Total synthesis of the phospholipomannan (PLM) which was found in cell wall of Candida albicans. It is most widespread human pathogen responsible for cutaneous and systemic fungal infections, synthesize a unique sequences of β-1,2-oligomannan on its cell surface that act as adhesion, induce production of pro-inflammatory cytokines and antibodies. And it is highly immunogenic due to its β-1,2-mannan structural motif, which is absent in human host. The PLM is a strong TNF-α inducer in vivo and in vitro. The target molecule contain synthetic challenges such as an unusual β-1,2-oligomannan, Anomeric phosphodiester and phyto sphingosine linked to saccharide through phosphate.
Publications
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Mahajan, V.; Sharma, N.; Kumar, S.; Bhardwaj, V.; Ali, A.; Khajuria, R. K.; Bedi, Y. S.; Vishwakarma, R. A.; Gandhi, S. G. Production of rohitukine in leaves and seeds of Dysoxylum binectariferum: An alternate renewable resource. Pharm Biol. (2015), 53, 446-450.
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Kumar, S.; Pathania, A. P.; Nalli, Y.; , Malik, F. A.; Vishwakarma, R. A.; Ali, A. Synthesis of new O-alkyl and alkyne–azide cycloaddition derivatives of 4'-methoxy licoflavanone: a distinct prenylated flavonoids depicting potent cytotoxic activity. Med. Chem. Res. (2015), 24, 669-683.
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Kumar, S.; Pathania, A. S.; Satti, N. K.; Dutt, P.; Sharma, N.; Mallik, F. A.; Ali, A. Synthetic modification of hydroxychavicol by Mannich reaction and alkyne-azide cycloaddition derivatives depicting cytotoxic potential. Eur. J. Med. Chem. (2015), 92, 236-245.
