Dr. Sanghapal D. Sawant
Microbial Biotechnology
Medical Chemistry
Council of Scientific and Industrial Research (CSIR)
India
Biography
He is a Senior Scientist at the CSIR(Council of Scientific & Industrial Research)-Indian Institute of Integrative Medicine, India.
Research Interest
Medicinal chemistry of natural product scaffolds for cancer drug discovery: In our cancer drug discovery program we are looking for isoform selective inhibitors of PI3K(α/β/γ/δ)/Akt-(1/2)/mTOR. The natural product scaffolds like liphagane is explored for its potential as selective PI3K inhibitor by medicinal chemistry approach. In vitro cell free and cell based screening of analogs is carried at intial stage, the active hits are identified. PK parameters, preformulation studies and physicochemical studies of NCEs of this scaffold are performed. The leads are being studied for their in vivo potential.
Publications
-
Venkateswarlu, V.; Aravinda Kumar, K. A.; Gupta, S.; Singh, D.; Vishwakarma R.;. Sawant, S. D. DMSO/I2 mediated C‒C bond cleavage of α-ketoaldehydes followed by C‒O bond formation: A metal-free approach for one-pot esterification. Organic and Biomolecular Chemistry (2015), 13, 7973-7978.
-
Srinivas, M.; Hudwekar, A. D.; Venkateswarlu, V.; Reddy, G. L.; Aravinda Kumar, K. A.; Vishwakarma, R. A.; Sawant, S. D. A metal-free approach for transamidation of amides with amines in aqueous media. Tetrahedron Letters, 2015, 56(33), 4775–4779.
-
Venkateswarlu, V.; Pathania, A. S.; Aravinda Kumar, K.A.; Mahajan, P.; Nargotra, A.; Vishwakarma, R. A.; Malik, F.A.; Sawant, S.D. 4-(N-phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as Inhibitors of Mammalian Target of Rapamycin. Bioorganic & Medicinal Chemistry (2015), 23(15), 4237-4247.
