Dr. Syed Sajad Hussain
Senior Scientist
Cancer Pharmacology
Council of Scientific and Industrial Research (CSIR)
India
Biography
He is a Senior Scientist at the CSIR(Council of Scientific & Industrial Research)-Indian Institute of Integrative Medicine, India.
Research Interest
Chromatin is a repeated structure of small bead like structures called Nucleosomes core particles (NCP), connected by a small piece of DNA called linker DNA. The NCP in turn, is composed of two copies each, of four basic histone, namely H2A, H2B, H3 and H4. These basic histones are well conserved protein with a central well structured protein domain called “histone fold” and unstructured N- and C terminal tails. The histone folds of individual histones interact with each other through hand shake motif interactions to form the octamer. This octamer interacts directly with the DNA (minor grooves) wrapped around it to complete the NCP. The tails are floating out of the NCP and are main targets for the post translation modification which have role in chromatin dynamics and function. There are, however, some modifications also reported for the aminoacid residues present in the histone fold domain (e.g. H3k79) which have roles in different cellular processes. Our lab is interested to study the role of small molecules, which can target epigenetic modifications relevant to cancer and Induced pluripotent stem cell generation.
Publications
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Dar, M.S.; Singh ,P.; Singh, G.; Jamwal, G.; Syed, S.H.; Rana, A.; Akhter ,Y.; Monga, S.P.; Dar, M.J. Terminal regions of β-catenin are critical for regulating its adhesion and transcription functions. Biochim Biophys Acta. (2016) ,1863(9):2345-57.
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Nalli ,Y.; Gupta, G.; Nadkarni ‘,R.J.; Gupta, V.K.; Syed, S.H.; and Ali, A. Divergent synthesis of prenylated carbazole alkaloid (+)-S-mahanimbine led to the discovery of a notch activator. RSC Adv. (2016),6, 83069-83077
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Bednar, J.; Garcia-Saez, I.; Boopathi, R.; Cutter, A.R.; Papai ,G.; Reymer, A.; Syed, S.H.; Lone, I.N.; Tonchev, O.; Crucifix, C.; Menoni, H.; Papin, C.; Skoufias, D.A.; Kurumizaka, H.; Lavery, R.; Hamiche, A.; Hayes, J.J.; Schultz, P.; Angelov, D.; Petosa, C.; Dimitrov ,S. Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. Mol Cell. (2017) ,66(3):384-397.e8.
