Anthony Addlagatta
Principal Scientist
Chemical Technology
CSIR-Indian Institute of Chemical Technology
India
Biography
Dr. Anthony Addlagatta has obtained his bachelor’s degree with specialization in industrial chemistry from Osmania University, masters and the PhD degrees in Chemistry from the School of Chemistry, University of Hyderabad. He has worked as a senior scientist at the Department of Energy, Pacific Northwest National Laboratory, USA before joining Indian Institute of Chemical Technology (IICT), Hyderabad. He was awarded with Mianowski International Fellowship from the Polish Academy of Sciences, Poland and Ramanujan Fellowship by the Department of Science and Technology, New Delhi. He has published over 55 research articles and a book chapter. His research interest is to understand the chemical principles in biological functions and, apply it to human health and biotechnology. His technical expertise includes chemistry, biochemistry, protein engineering, molecular, structural, cellular and computational biology, bioinformatics, structure based drug discovery and biotechnology. He also serves as an inspector on behalf of the Government of India for companies that adopt Good Laboratory Practice.
Research Interest
His research interest is to understand the chemical principles in biological functions and, apply it to human health and biotechnology. Specific interests are to understand the substrate binding binding pockets of enzymes and use this knowledge in design of specific inhibitors. Molecular are synthesized and retested on the recombinant enzymes, cell lines and animal models. Current projects include methionine aminopeptidase, aminopeptidases N,His technical expertise includes chemistry, biochemistry, protein engineering, molecular, structural, cellular and computational biology, bioinformatics, structure based drug discovery and biotechnology.
Publications
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T. Arya, R. Reddi, C. Kishor, R.J. Ganji, S. Bhukya, R. Gumpena, S. McGowan, M. Drag, A. Addlagatta* 2015 Identification of the molecular basis of inhibitor selectivity between the human and Streptococcal Type I methionine aminopeptidases. J. Med. Chem., 12, 2350-7.
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Reddi R, Singarapu KK, Pal D, Addlagatta A.* 2016 The unique functional role of the C-H...S hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase. Mol. Biosys. 12, 2408-2416.