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Nishant Jain S

Principal Scientist
Chemical Technology
CSIR-Indian Institute of Chemical Technology
India

Biography

Dr. Nishant Jain S is affiliated to the Department of Chemical Technology, CSIR-Indian Institute of Chemical Technology. Dr. Nishant Jain S is currently providing services as Principal Scientist. Dr. Nishant Jain S has authored and co-authored multiple peer-reviewed scientific papers and presented works at many national and International conferences. Dr. Nishant Jain S contributions have acclaimed recognition from honourable subject experts around the world. Dr. Nishant Jain S is actively associated with different societies and academies. Dr. Nishant Jain S academic career is decorated with several reputed awards and funding. Dr. Nishant Jain S research interests include We folks, work on the regulation of enzymes involved in tumour metabolism. Presently, we are focused on the enzymes isocitrate dehydorgenases-1 and -2. These enzymes are often mutated in a wide spectrum of cancers, and demonstrate a gain of function. Hence we use molecular biology tools to delineate the mechanisms involved in regulating these enzymes. In addition, we also plan to expand our forte, by investigating the link between RNA epigenetics (N6-Methyladenosine) and tumour metabolism..

Research Interest

We folks, work on the regulation of enzymes involved in tumour metabolism. Presently, we are focused on the enzymes isocitrate dehydorgenases-1 and -2. These enzymes are often mutated in a wide spectrum of cancers, and demonstrate a gain of function. Hence we use molecular biology tools to delineate the mechanisms involved in regulating these enzymes. In addition, we also plan to expand our forte, by investigating the link between RNA epigenetics (N6-Methyladenosine) and tumour metabolism.

Publications

  • Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy. Vangala JR, Dudem S, Jain N, Kalivendi SV. J Biol Chem. 2014 289,12612-22.

  • Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers.Kamal A, Reddy VS, Shaik AB, Kumar GB, Vishnuvardhan MV, Polepalli S, Jain N.Org Biomol Chem. 2015, 13, 3416-31.

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