Srinivas Kantevari
Scientist
Chemical Technology
CSIR-Indian Institute of Chemical Technology
India
Biography
Srinivas Kantevari obtained his Ph.D. (1996) from Department of Chemistry, Indian Institute of Technology (IIT), New Delhi. He was research associate (1996-97) at National Institute of Immunology (NII) New Delhi. Later, he was a post-doctoral fellow (2001-2003) and research associate (2006-2008) with Prof. Graham Ellis-Davies, Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia,USA. He has been associated with Indian Institute of Chemical Technology (IICT) since 1997. Presently, he is sr.scientist at Indian Institute of Chemical Technology (IICT), Hyderabad. His research interests are broad based which include development of new photolabile compounds to control cellular chemistry, development new drug candidates and imaging agents for probing Alzheimer’s disease (AD), receptor targeted approaches for the development of new chemical entities, fragment based approaches for drug design and discovery. He has been able to successfully carry out extensive basic and applied research investigations in the chemistry of new molecules derived from natural products of biological relevance.Presently, 8 students are working for Ph.D. and 4 students for master’s dissertation work. He has 66 publications and 5 patents for his credit. He is an editorial board member for Open Journal of Catalysis, member, and editorial board of reviewers for ARKIVOC, and expert reviewer for various journals of international reputation. He also developed several processes for APIs and drug molecules of interest and involved in transferring the technologies.
Research Interest
Design, synthesis and evaluation of novel antitubercular agents, Dual inhibitors for cardiovascular diseases, Inhibitors targeting NLRP3 inflammasome cascade for treating Type 2 Diabetes, Development of new photolabile compounds to control cellular chemistry and physiology using photo release technology, Development of imaging agents for probing Alzheimer’s Disease (AD), Receptor targeted approaches for the development of new chemical entities, i) New molecules as Ryanodine receptor activators ii) Structure-activity relationship of Oxadiazine compounds with voltage gated sodium channels for agrochemical use Synthesis of novel calix-pyrroles and calix-benzodipyrroles for ionic and molecular recognition in solution and gas phase, Logic-based Single Reactant Replacement (SRR) approaches for multi-component reactions (MCRs), Dendrimer chemistry, Heterocyclic chemistry.
Publications
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Facile diversity-oriented synthesis and antitubercular evaluation of novel aryl and heteroaryl tethered pyridines and dihydro-6H-quinolin-5-ones derived via variants of Bohlmann-Rahtz reaction. Srinivas Kantevari*, Santhosh Reddy Patpi, Dinesh Addla, Siddamal Reddy Putapatri, Balasubramanian Sridhar, Perumal Yogeeswari and Dharmarajan Sriram. ACS Comb. Sci., 2011, 13, 427-435.
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Design, synthesis and structure-activity correlations of novel dibenzo[b,d] furan, dibenzo[b,d]thiophene and N-methylcarbazole clubbed 1,2,3-triazoles as Potent Inhibitors of Mycobacterium tuberculosis. Santhosh Reddy Patpi, Lokesh Pulipati, Perumal Yogeeswari, Dharmarajan Sriram, Nishant Jain, Balasubramanian Sridhar, Ramalinga Murthy, Anjana Devi T, Shasi Vardhan Kalivendi, and Srinivas Kantevari* J. Med. Chem., 2012, 55 (8), pp 3911–3922.
