Ajay K. Yadav

Biography

Dr. Ajay K. Yadav started his research career from Industrial toxicology Research center, Lucknow & National Institute of Immunology, New Delhi and PhD from Jamia Hamdard University, New Delhi in the field of Tumor Necrosis Factor- alpha biology. After finishing PhD, Dr. Ajay Kumar moved to Northwestern University, IL(USA), worked for 3-years with Dr. Goberdhan Dimri's laboratory where he studied the deregulated expression of Polycomb proteins at the stage of breast cancer metastasis. Latter he joined Prof. Markus Bredel laboratory where he involved in Glioma genome wide mapping identified novel genetic signatures present in a subsets of Glioblastoma tumor tissues required for disease malignancy.

Research Interest

Current research area is identification and characterization of novel alternative spliced variant. Alternative spliced variant genes are usually of different genetic sequences and conformation formed at the state of pre-mRNA splicing. Skipping of relevant exons leads to formation of alternative proteins with gain or loss of functions required for stability/de-stability of gene or translated protein. So, tumor suppressor with loss of exons usually go with loss of function are usually formed at accelerated rate during cancer disease progression along with loss of exons in oncogenes seems to deprived of translated protein with domain required for degradation signal, inferred with loss or gain in original gene function. Goal to study the involvement of genetic spliced variant with their relative alternative pathway expression at different diseased state.