Kamna Srivastava

Biography

Dr Kamna Srivastava did her B. Pharm, M. Pharm and PhD from Department of Pharmacology, Institute of Technology from Bananas Hindu University. She has past experience by working at National Institute of Immunology, New Delhi as a Pool-Officer under a CSIR guided project after which she joined All India Institute of Medical Sciences, New Delhi as a postdoctoral fellow.

Research Interest

Molecular cardiology, Pharmacogenomics, Toxicology and Pharmacology Cardiovascular diseases (CVD) are one of the major causes of mortality worldwide. Based on their antioxidant and inflammatory potential, candidate genes associated with cardiovascular diseases including various isoforms of Heat Shock Proteins, microRNAs, PCSK9 and various novel biomolecules, our lab is working on developing these molecules in to non-invasive and more effective circulating prognostic biomarkers as compared to the already existing markers used in CVD prognosis and diagnosis. Our laboratory has studied extensively the role of gene and proteins encoding Renin Angiotensin Aldosterone system on blood pressure control with ACE inhibitors in north Indian subjects with essential hypertension. Presently, lab focuses on studying the regulatory function and signaling crosstalk mediated by small non coding RNAs (sncRNAs) such as miRNAs in coronary artery disease (CAD) and to develop these non-coding RNAs as therapeutic targets as well as potential biomarkers in cardiovascular diseases. In another objective, our laboratory has been studying the role of Heat Shock Proteins gene polymorphisms, expression in whole blood and their correlation with plasma inflammatory markers in North Indian subjects with cardiovascular disorders. In a recent effort to develop biomarker based on lipid parameters, our lab is looking into the pathophysiological mechanism of PCSK9 inhibitors in patients with CAD.