Laishram R. Singh

Biography

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Research Interest

Neurodegenerative disorders are becoming a significant cause for the increasing proportion of mortality in the developed world. One of the common hallmark and unifying characteristic of all neurodegenerative diseases is the presence of toxic protein deposits (oligomers) either intracellularly or extracellularly. In recent years an increased level of homocysteine in the blood plasma has been linked with the promotion of neurodegenerative disorders. The exact mechanism how protein deposits or increase in the level of homocysteine leads to neuronal death (neurodegenerative diseases) has not been unveiled. Currently, Dr. Singh’s laboratory is interested in investigating neurodegenerative disorders caused due to homocysteine toxicity and due to toxic protein deposits in neuronal cells. In another project the laboratory is also interested in using proteostatic modulators (drugs that can modulate protein quality control system) for the therapeautic intervention of leukemia.