Madhu Chopra
Assistant Professor
Molecular Modelling and Anticancer Drug Development
Dr B R Ambedkar Center for Biomedical Research
India
Biography
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Research Interest
1. Drug Development and mechanism 2. Molecular Modeling, Drug Design and Bioinformatics 3. Nanotechnology: Nanomaterials and application in drug delivery We are doing active research in Computer Assisted Drug Design and Development. Using various computational methods such as pharmacophore modelling, 3D QSAR, virtual screening etc. we have identified several lead compounds against important cancer targets. Along with computational design my group is working towards development of anticancer compounds considering GPCR, HDAC and COX-2 as molecular Targets. The projects involve detailed mechanistic studies, protein-protein interaction networks (PPIs) of cancer targets in order to find effective combination therapy regimes against various cancer types. In addition, we are also pursuing synthesis of medicinally important compounds. Our group is also involved in isolating natural compounds having anticancer properties using cell based in vitro and in vivo screening methods. Nanoparticle based drug delivery agents is another area which our group is working to give target specific pharmaceutical agents
Publications
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3. Strong Anti-tumorous Potential of Nardostachys jatamansi Rhizome Extract on Glioblastoma and In Silico Analysis of its Molecular Drug Targets, Himanshi Kapoor, Nalini Yadav, Madhu Chopra, Sushil Chandra Mahapatra, Veena Agrawal, Curr Cancer Drug Targets. 2017, 17(1) , 74-88.
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2. Parveen Kumar, Nalini Yadav, Aruna Chhikara, Madhu Chopra Combinatorial Solid Phase Synthesis: Techniques, Characterization and its Application in Drug Development, Current Biochemical Engineering, 2017, Vol 4 (1), 9-33. 10.2174/2212711903666160622085741.
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1. Identification of Potent Cholecystokinin-B Receptor Antagonists: Synthesis, Molecular Modeling and anti-cancer activity against Pancreatic Cancer Cells., Saroj Kumari, Joyita Chowdhury, Manisha Sikka, Priyanka Verma, Prakash Jha, Anil K. Mishra, Daman Saluja and Madhu Chopra* Med. Chem. Commun., 2017, Accepted Manuscript (DOI: 10.1039/C7MD00171A)
