Manisha Yadav

Biography

Dr. Manisha Yadav did her Ph.D. from Post Graduate Institute of Medical Education and Research, Chandigarh, India. During that time she was awarded “Major General Amir Chand Medal for Research” for her PhD work. After her PhD, she initially joined as a Postdoctoral fellow and later as Research Assistant in the Department of Microbiology, Immunology and Glycobiology of Lund University, Sweden. During this time, she worked to investigate the molecular basis of host cell signalling in innate immune responses to uro-pathogenic Escherichia coli and the disease association of the responsible genes.

Research Interest

Dr Manisha is working to identify the host receptors and the host-parasite’s pathways involved in the symptomatic and asymptomatic sequelae and immune evasion caused by Trichomoniasis, Sepsis and Urinary Tract Infections (UTI). Since there is an urgent need to understand and prevent the negative impact of this parasite on women’s reproductive health and to prevent the risk of other associated sexually transmitted diseases. We are also working to identify the host molecules responsible for acute inflammation and particular virulence factors triggering the inflammatory pathway after Uropathogenic E.coli (UPEC) infection. Ultimately identification of target molecules either in the host or in bacteria may prove to be a better approach to win over this disease. The complexity of the acquisition and spread of Multiple Drug Resistant phenotypes pose a significant threat to human health. As they entail serious therapeutic challenges due to their ability to withstand the effect of different classes of antimicrobial agents. So there is an urgent need to update the antibiotic resistant pattern prevalent worldwide for improving the empirical prescription of general practitioners regarding antibiotics usages during most common community acquired infections like UTI. There is also a need of investigating the mechanism behind antibiotic resistance by devising different strategies in order to better understand such diseases. We are looking out for a possible mechanism or factor(s) behind the antibiotic resistance by investigating antibiotic susceptibility pattern and clonal group pattern in E. coli worldwide, along with our international collaborators. These studies will be helpful to understand the role of antibiotic susceptibility pattern & clonal groups, which can be further exploited as a therapeutic means for the treatment of UTI infection.