Pratibha M. Luthra
Associate Professor
Dr. B.R. Ambedkar Center for Biomedical Research
Dr B R Ambedkar Center for Biomedical Research
India
Biography
Dr. Luthra is a Associate Professor at Dr. B.R. Ambedkar Center for Biomedical Research. Dr. Luthra work focuses on i) the study of the signaling pathways in brain to explore the nNOS mediated oxidative stress leading to neurodegeneration in brain and ii) discovery of new chemical entities (NCE) in the therapy of Parkinson's disease ( PD) through adenosine A2ARs. iii) The work also involves to explore the molecular pathways in the pathology of GBM, which may reveal multiple targets for the treatment of GBM to address drug resistance and provide specificity and selectivity in cancer chemotherapy.
Research Interest
Dr. Luthra work focuses on i) the study of the signaling pathways in brain to explore the nNOS mediated oxidative stress leading to neurodegeneration in brain and ii) discovery of new chemical entities (NCE) in the therapy of Parkinson's disease ( PD) through adenosine A2ARs. iii) The work also involves to explore the molecular pathways in the pathology of GBM, which may reveal multiple targets for the treatment of GBM to address drug resistance and provide specificity and selectivity in cancer chemotherapy.
Publications
-
Bis ((1, 4-dimethyl-9 H-carbazol-3-yl) methyl) amine-mediated anticancer effect triggered by sequence-specific cleavage of DNA leading to programmed cell death in the human U87 cell line N Kumar, R Kumar, V Nemaysh, N Lal, Pratibha M Luthra, RSC Advances 6 (72), 67925-67940, 2016.
-
Prospective of curcumin, a pleiotropic signalling molecule from Curcuma longa in the treatment of Glioblastoma, Pratibha Mehta Luthra, Neetika Lal European Journal of Medicinal Chemistry Volume 109, 15 February 2016, Pages 23–35.
-
Pharmacological assessments of potent A2A receptor antagonist IDPU (1-(7-imino-3-propyl-2,3-dihydrothiazolo[4,5-d]pyrimidin-6(7H)-yl)urea) in rodent model of Haloperidol induced Parkinson like symptoms. Kumari,, N, Agarwal S & Pratibha M. Luthra Neuroscience Letters 647, 53-60 2017.
