Benu Brata Das
Assistant Professor
Physical Chemistry
Indian Association for the Cultivation of Science
India
Biography
Senior Visiting Professor 2016 (September to December), Institute of Advanced Studies, Department of Pharmacy and Biothechnology, University of Bologna, Bologna, Italy. http://www.isa.unibo.it/en/visiting-fellows/benu-brata-das UK-Wellcome Trust / DBT- India Alliance Intermediate Fellow 2013. http://www.wellcomedbt.org/fellowsprofile/dr-benu-brata-das-185 Assistant Professor at IACS (2012 Dec onward to present). Full Time Federal Employee (FTE) at the National Institutes of Health, Developmental Therapeutic Branch, Laboratory of Molecular Pharmacology, Centre for Cancer Research, National Cancer Institute, , USA. 2011-2012 Post doctoral Fellow, National Cancer Institute, National Institutes of Health, USA with Dr. Yves Pommier, chief Laboratory of Molecular Pharmacology. 2006-2011 Ph.D (Molecular Biology & Biochemistry), Indian Institute of Chemical Biology, Kolkata, India with Dr. Hemanta K. Majumder. 2001-2006 (Degree awarded by Jadavpur University)
Research Interest
1. DNA Topoisomerase structure, cellular and biochemical functions. 2. Explore the molecular mechanisms of Top 1cc-induced DNA lesions and Tyrosyl-DNA phosphodiesterase 1 (TDP1) mediated DNA repair. 3. Explore new DNA repair pathways in mitochondria and the role of mtDNA damage in human diseases. 4. Explore the role of post-translational modifications (PTMs i.e. phosphorylation, acetylation, methylation, ubiquitylation and SUMOylation) of DNA repair proteins and response to anticancer agents. 5. Unravel the functional and biological coupling of Poly(ADP-ribose)polymerase (PARP1) with DNA repair pathways. 6. Explore the molecular mechanism of PARP inhibitors in cancer treatment. 7. Anticancer Drug Discovery: Targeting DNA Topoisomerase with small molecules inhibitors in human cancer.
Publications
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Nature India: Combo therapy against drug-resistant cancers : http://www.natureasia.com/en/nindia/article/10.1038/nindia.2016.127
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Das, S.K., Rehman, I., Ghosh, A., Sengupta, S., Majumder, P., Jana, B and Das BB*. Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells. Nucleic. Acids Research., 2016, 44, 8363-75.. http://www.ncbi.nlm.nih.gov/pubmed/27466387
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Maji S, Alam P, Kumar GS, Biswas S, Sarkar PK, Das B, Rehman I, Das BB, Jana NR, Laskar IR, Acharya S. Induced Aggregation of AIE-Active Mono-Cyclometalated Ir(III) Complex into Supramolecular Branched Wires for Light-Emitting Diodes. Small. 2017 Jan 30. doi: 10.1002/smll.201603780. [Epub ahead of print]
