Dr. Anju Pappachan
Assistant Professor
Bioinformatics & Structural Biology
Indian Institute of Advanced Research, IIAR
India
Biography
Her education includes: PhD: 2009 from Molecular Biophysics Unit, Indian Institute of Science,Bangalore and M.Sc: 2003 from Tamil Nadu Agricultural University, Coimbatore. Her resaerch area includes: Leishmaniasis is a spectrum of diseases caused by the protozoan parasite Leishmania sp.Visceral leishmaniasis caused by Leishmania donovaniis the most fatal. High toxicity and cost of current treatments and the emergence of drug resistant parasites point to an urgent need for the development of new classes of drugs against Leishmania. In this context, novel drug targets have to be identified.A rational approach to develop new drugs is to identify metabolic differences between the host and parasite and exploit those proteins which are crucial for the survival of the parasite, at the same time not significant for the host as drug targets. Their group is involved in characterizing proteins belonging to the purine salvage pathway of Leishmania donovani.
Research Interest
Bioinformatics & Structural Biology
Publications
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Singh V., Nair D., Kaushal R. S., Kumar M., Pappachan A., Singh D. D. (2015) Heterologous expression, purification and characterization of L-type lectin homologue from Leishmania donovani. Biotechnology Reports, 8: 81-87. doi:10.1016/j.btre.2015.09.004
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Shah KR, Patel DK, Pappachan A, Prabha CR, Singh DD. (2015) Characterization of a Kunitz-type serine protease inhibitor from Solanum tuberosum having lectin activity. Int J Biol Macromol. 83;259-69.
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Patel D. K., Shah K. R. , Pappachan A., Gupta S., Singh D. D. (2016) Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. http://dx.doi.org/10.1016/j.ijbiomac.2016.04.041
