Dr. Himanshu Kumar
Associate Professor
Biological Sciences
Indian Institute of Science Education and Research, Bhopal
India
Biography
Associate Professor (August 2016-till date), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India. Assistant Professor (July 2010-July 2016), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India. Adjunct Associate Professor. (March 2010-till date),World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan. Associate/ Section Editor (May 2012 - till date), International Reviews of Immunology, Informa Healthcare press. JSPS Post-doctoral Fellow (April 2008-March 2010), Laboratory of Host Defense, World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan. Ph.D.[April 2004-March 2008 as Japanese Government Fellow (MEXT Fellow)], Immunobiology, Graduate School of Medicine, Osaka University, Japan with Professor. Shizuo Akira.
Research Interest
Innate immunity is first line of defense system and promptly activated after microbial infection to initiate protective responses through production of inflammatory cytokines from various immune cells. Innate immune system consists of humoral components such as complements, acute phase proteins and cellular components such as Monocytes, Macrophages, Dendritic cells, Eosinophils, Basophils, Neutrophils, Mast cells and Natural-killer cells. The humoral components have a broad range of actions against microorganisms, including gram-positive and gram-negative bacteria, fungi and viruses. The cellular components either directly kill the microbial pathogens through phagocytosis or induce production of cytokines, which helps in the elimination of pathogens. The innate immune cells express various pattern recognition receptors (PRRs) which recognize signature molecules of the pathogen. These signature molecules are essential for the survival of the pathogen and known as a pathogen associated molecular pattern (PAMPs). These PRRs recognizes different PAMPs of the pathogen in various compartments of the cells and trigger induction of inflammatory cytokines for the host defense. Furthermore, the innate immune responses are also required for the development of the pathogen specific adaptive immunity through B and T lymphocytes.
Publications
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Mohan Reddy Bodireddy Ranjeet Singh Mahla P Md Khaja Mohinuddin G Trivikram Reddy D Vijaya Raghav Prasad Himanshu Kumar Discovery of a new class of 16-membered (2Z, 11Z)-3, 11-di (aryl/naphthyl)-1, 13-dioxa-5, 9-dithia-2, 12-diazacyclohexadeca-2, 11-dienes as anti-tumor agents RSC Advances 2016 Pradip B Ranaware Anamika Mishra Periyasamy Vijakumar Pradip N Gandhale Himanshu Kumar Diwakar D Kulkarni Ashwin Ashok Raut Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses PLoS One 2016 Mohammed Fawaz Periyasamy Vijaykumar Anamika Mishra Pradip N Gandhale Rupam Dutta Nitin M Kamble Shashi B Sudhakar Parimal Roychoudhary Himanshu Kumar Diwakar D Kulkarni Ashwin Ashok Raut Duck gut viral metagenome analysis captures snapshot of viral diversity. BMC Genomics 2016 Puja Kumari Sathish Narayanan Himanshu Kumar Herpesviruses: interfering innate immunity by targeting viral sensing and interferon pathways Reviews in Medical Virology 2015 Sushil Kumar Harshad Ingle Shalabh Mishra Ranjeet Singh Mahla Ashish Kumar Taro Kawai Shizuo Akira Akinori Takaoka Ashwin Ashok Raut Himanshu Kumar IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependnt and independent anticancer activity Cell Death and Disease 2015 Harshad Ingle Sushil Kumar Ashwin Ashok Raut Anamika MIshra Diwakar Dattatraya Kulkarni Takeshi Kameyama Akinori Takaoka Shizuo Akira Himanshu Kumar The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication Science Signaling 2015
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Himanshu Kumar Adrian Bot Antibodies in pathogenesis and management of diseases International Reviews in Immunology 2017
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Himanshu Kumar Adrian Bot Innate immunity and infectious diseases–An update International Reviews in Immunology 2017
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Himanshu Kumar Adrian Bot Role of MicroRNAs in shaping innate immunity and as therapeutic targets for autoimmune diseases International Reviews in Immunology 2017
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Himanshu Kumar Adrian Bot Role of immune cells, immune modulating factors and immunotoxins in cancer immunotherapy International Reviews in Immunology 2017
