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Dr. Sachin Deshmukh

Assistant Research Scientist
Neuroscience
Indian Institute of Science
India

Biography

Dr. Sachin Deshmukh received his B.Sc. degree in Microbiology and M.Sc. degree in Molecular biology. He received his PhD from National Centre for Biological Sciences, Bangalore. After his postdoctoral work at University of California, Berkeley, USA; University of Texas Health Science Center, Houston, USA; Johns Hopkins University, Baltimore, USA, he joined the Centre for Neuroscience at the Indian Institute of Science, Bangalore. As a postdoc and subsequently as an Assistant Research Scientist in Dr. James J. Kneirim's lab, he has been working on elucidating spatial and nonspatial representations in the entorhinal cortical inputs to the hippocampus. He has continued to incorporate technological advances in his research like he uses Computer Aided Design and 3D printing technology for manufacturing hyperdrives used for neuronal recordings, and have beta tested a 64 channel wireless recording system for recoding neuronal data from awake, behaving rats. Both these techniques are now routinely used in Knierim lab.

Research Interest

Neural mechanisms of learning and memory. Our primary research interest is to understand how the hippocampal network creates a coherent representation of events within their spatial context. Unravelling the interplay of sensory-derived spatial and nonspatial information brought in by LEC and the internally generated, path-integration-based spatial representation in MEC is a crucial step in this endeavour.

Publications

  • Deshmukh SS, Knierim JJ. Influence of local objects on hippocampal representations: Landmark vectors and memory. Hippocampus. 2013 Apr 1;23(4):253-67.

  • Knierim JJ, Neunuebel JP, Deshmukh SS. Functional correlates of the lateral and medial entorhinal cortex: objects, path integration and local–global reference frames. Phil. Trans. R. Soc. B. 2014 Feb 5;369(1635):20130369.

  • Deshmukh SS. Spatial and nonspatial representations in the lateral entorhinal cortex. InSpace, Time and Memory in the Hippocampal Formation 2014 (pp. 127-152). Springer Vienna.

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