Swananda Marathe
Inspire faculty fellow
Department of Neuroscience
Indian Institute of Science
India
Biography
Although how neurons influence behavior has been investigated in great detail, there has been little clarity on the role played by astrocytes, a far more abundant cell type, in orchestrating behavior. Astrocytes form an integral part of the synaptic machinery and a single astrocyte can contact and influence the function of about 1,00,000 synapses. They are highly important for normal synaptic function and many brain disorders are associated with astrocytic dysfunction. We are interested in studying how astrocytes and neurons communicate with each other to modulate synaptic plasticity. We investigate the role of astrocytes in behavior with a particular emphasis on mood-related disorders such as anxiety and depression. We are currently studying Jagged-Notch signaling at astrocyte-neuron interfaces.
Research Interest
Role of astrocytes in behavior and disease
Publications
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Brai E, Marathe S, Astori S, Fredj NB, Perry E, Lamy C, Scotti A, Alberi L. Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling. Frontiers in cellular neuroscience. 2015;9.
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Husain BF, Nanavaty IN, Marathe SV, Rajendran R, Vaidya VA. Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2015 Aug 3;61:1-9.
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Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell death and differentiation. 2015 Nov;22(11):1775.
