Dr. Srikanta Patra

Biography

PhD Thesis Title : Mixed-Valency in Polyruthenium Systems Year : August, 2001 – November, 2005 Supervisor : Prof. G. K. Lahiri Institute : Indian Institute of Technology, Bombay (IIT, Bombay) Postdoc Research Topic : Small molecule activation using late transition metal complexes Year : 2006–2007 Institute : The University of Iowa, USA Research Topic : Development of nanoparticle-based biosensor Year : 2007–2009 Institute : Pusan National University, South Korea Teaching Theory : General Chemistry I, Chemistry of Materials, Design of Application of Nanomaterials, Analytical Chemistry, Physical Methods in Inorganic Chemistry. Awards:  Received Outstanding Research Award in Science for the year 2005, IIT Bombay.  Awarded Senior Research Fellowship by UGC, New Delhi, India in 2004.  Awarded Junior Research Fellowship by CSIR New Delhi, India in 2002.  Awarded Junior Research Fellowship by UGC, New Delhi, India in 2001.  Qualified in All India level Graduate Aptitude Test in Engineering (GATE–2001).  Received Minakshi Lalit Award in Chemistry, by Gujarat Science Academy in 2000.

Research Interest

Metal Mediated Organic Transformations (Catalysis), Metal Based Anticancer Drugs, Functional Materials, Luminescent Materials, Sensors, Research Activities in the Coordination Chemistry and Materials Chemistry Laboratory: Our research group is primarily focused on two aspects (a) development of embellished transition metal complexes comprising suitable ligand framework and (b) multimetallic core-shell type solid/porous or metal modified nanoparticles, to explore their suitable applications in the area of metal based chemotherapeutic agents and catalysis and sensors. In this context, our research group is engaged in design and development of suitable ligand frameworks (polypyridyl and polypyrazole) and their corresponding mono-, di- and heterodinuclear complexes of ruthenium, iridium and palladium and platinum. Such complexes are anticipated to exhibit selectivity towards inhibiting various kinases, better anticancer activity with less toxicity and induce natural product-like non-apoptotic mode of cell death. Our novel observation suggests that tuning the coordination environment (hydrophobicity) around the metal centre, the efficiency and mode of cell death can be controlled. Understanding the metal mediated alteration of cell death mechanism and identifying the controlling parameters associated with this could be useful and promising for the development of efficient anticancer agents for resistant cancer. Ref. Dalton Trans., 2014, 43, 14546; ChemMedChem., 2016, 11, 1410 The second goal of our research group is the development of efficient bifunctional catalyst systems of the combination of Ru-Pd, Ir-Pd and Ir-Ru for various mechanistically diverse one-pot multi-step reactions (tandem reactions). Our group is involved in controlling the crucial parameters such as the intermetallic distance, conjugation and cooperative interaction by designing suitable bridging and ancillary ligand frameworks for achieving efficient heterodimetallic complexes with improved reactivity, selectivity and efficiency. Ref. Dalton Trans., 2014, 43, 16597: ACS Catal., 2016, acscatal.6b01421 The third area of our research program is the development of multimetallic core-shell type porous/solid or metal modified nanoparticles to improve the properties and reactivity via the cooperative interaction and self-assembly. We are deeply involved in developing multimetallic nanoparticles systems of second and third row transition metals for their use in designing sensors, efficient catalyst systems for organic transformations, electrocatalyst for various electrochemical reactions, waste water treatment, etc. Ref. J. Mater. Chem. A, 2015, 3, 19376.