Mahitosh Mandal
Associate Professor
School of Medical Science and Technology
Indian Institute of Technology (IIT) Kharagpur
India
Biography
Mahitosh Mandal : Associate Professor School of Medical Science and Technology
Research Interest
Research Statement Selected Publications Current Projects Group Members Dr. Mahitosh Mandal has made outstanding contribution in cancer research. He has identified specific genes and their biological functions in various cancers. In USA Lab., he has cloned Metastasis Associated gene 1 with ER-binding motif which stimulates malignant phenotypes. Also he discovered a link between telomerase activity and cancer progression. While at IIT, Kharagpur, he established a new Division of Cancer Biology where he has made significant contribution in developing newer targets for treatment and prevention of cancer. He showed that incorporation of an anti-EGFR molecule with VEGFR for chemotherapy can be more effective in treating patients with locally advanced or metastatic breast cancer. Mahitosh has also shown that Diacerein, an IL-6 inhibitor offered a novel blueprint for cancer therapy by hampering IL-6 /STAT3/MAPK/Akt network but without any toxic effects. Presently, he is engaged in nanoparticle mediated drug delivery and has shown that celecoxib-loaded Hap- Cht nanoparticles in colon cancer can serve as an effective and safe means of delivering the drug. Currently, he along with a team of oncologist, physicist and engineers are trying to determine specific molecular, bio-physical and bio-electrical changes in cancer cells during malignant transformation and acquisition of chemo-radioresistance. An outstanding contribution of Dr. Mandal as evidenced by majority of his publications in high impact factor Scopus indexed journals.
Publications
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Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application by Kalita H., Kumar B. P., Konar S. , Tantubay S. , Mahto M. K., Mandal M. , Pathak A. Materials Science and Engg:C (Mater. for Bio. Appl.) 60 84-91 (2016)
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Silk fibroin nanoparticles support in vitro sustained antibiotic release and osteogenesis on titanium surface by Sharma S., Bano S. , Ghosh A. S., Mandal M. , Kim H. , Dey T. , Kundu S. C. Nanomedicine: Nanotechnology, Biology, and Medicine 12 1193-1204 (2016)
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GW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signalling by Parida S., Pal I., Parekh A., Thakur B. Bharti R,. Das S and Mandal M Cell Death and Disease 24;7:e2154 1-13 (2016)
