S.ganesh
Professor
Biological Science and Bioengineering
Indian Institute of Technology Kanpur
India
Biography
Dr. Ganesh received his PhD from Banaras Hindu University in 1996. After a short postdoctoral training in the Indian Institute of Sciences, Bangalore, he joined the RIKEN Brain Science (Japan) in February 1998 as a staff scientist. Dr. Ganesh joined the faculty of BSBE in April 2002
Research Interest
Neurodegenerative disorders are a group of central nervous system dysfunctions characterised by the progressive loss of neural tissues resulting in movement abnormalities, progressive decline in intellectual and cognitive functions, and in certain cases early death. A major research focus of Dr Ganesh's group is to identify and characterize molecular players in neurodegenerative pathways. For this, he conduct genetic screens in affected families and utilize cellular/animal models for testing and validating the hypothesis. Discovery of critical players in neurodegeneration is undoubtedly the first step towards developing effective therapeutics.
Publications
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Jain N, Rai A, Mishra R and Ganesh S* (2017) Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock. Cell Stress and Chaperones 22: 307-315.
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Upadhyay M, Agarwal S, Bhadauriya P, and Ganesh S* (2017) Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiology of Disease 100: 39-51
