Aditi Chatterjee
Bioinformatics
Institute of Bioinformatics (IOB)
India
Biography
Dr. Aditi Chatterjee obtained her Ph.D. degree in Biochemistry from the University of Calcutta, India. After completing her graduate studies, she joined the Johns Hopkins University School of Medicine in Baltimore, USA, as a Postdoctoral fellow in Radiation Oncology. Subsequently, she completed a Senior Postdoctoral Fellowship in the Division of Head and Neck Cancer Research in the Department of Otolaryngology at Johns Hopkins University School of Medicine, where she gained experience in translational research. She received the 'Young Clinical Scientist Award' from Flight Attendant Medical Research Institute, Florida, which enabled her transition to an independent Faculty position as an Instructor at Johns Hopkins University. She has investigated the role of cigarette smoke in the induction of chemotherapeutic resistance in bladder cancer and molecular mechanisms involved in mitochondrial DNA damage and repair in response to oxidative stress. At IOB she has established a research program on molecular dissection of oral cancer, which accounts for one of the highest noted cancers in India due to the use of chewing-tobacco. Her research focuses on molecular genetics and proteomic alterations that drives the progression of different types of cancer associated with tobacco. This includes head and neck squamous cell carcinoma (HNSCC), esophageal and lung cancer. She is specifically interested in the molecular epidemiology of tobacco-induced cancers and the link between tobacco use and mutations or proteomic alterations of critical oncogenes or tumor suppressor genes. She is using genomic and proteomic strategies to identify novel therapeutic targets for cancer and develop early detection markers using body fluids, including saliva and blood. She has served as the Senior Guest Editor for the Journal of Oncology for a special issue on Cigarette Smoke and Cancer. She has been a reviewer for PLOS One, Journal of Proteomics, FEBS Letters, Hematological Oncology, Scientific Reports and Oncotarget.
Research Interest
Proteomics approaches to identify biomarkers and therapeutic targets of lung, oral and esophageal squamous cell carcinoma Phosphoproteomic approaches to investigate aberrant regulation of kinase signalling pathways in cancers Role of miRNA in cancer progression
Publications
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Solanki, H. S., Advani, J., Kumar, M., Kumar, P., Bhagat, H., Prasad, T. S. K., Sidransky, D., Gowda, H., Chatterjee, A. (2017). miRNA profiling of bladder cells chronically exposed to cigarette smoke condensate and its vapor. Research Reports.
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Solanki, H. S., Babu, N., Jain, A. P., Bhat, M. Y., Puttamallesh, V. N., Advani, J., Raja, R., Mangalaparthi, K. K., Kumar, M. M., Prasad, T. S. K., Mathur, P. P., Sidransky, D., Gowda, H., Chatterjee, A. (2017). Cigarette smoke induces mitochondrial metabolic reprogramming in lung cells. Mitochondrion.
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anjappa, V., Sathe, G.J., Jain, A. P., Rajagopalan, P., Raja, R, Subbannayya, T., Patil, A. H., Kumar, P., Prasad, T. S. K., Mathur, P. P., Sidransky, D., Gowda, H., Chatterjee, A. (2017). Investigation of curcumin mediated signaling pathways in head and neck squamous cell carcinoma. Translational Research in Oral Oncology.
