Durg Vijai Singh
Scientist
Department of BioTechnology
Institute of Life Sciences, Nalco Square
India
Biography
Bachelor of Science: Banaras Hindu University (1982) Master of Science: Banaras Hindu University (1985) PhD: Banaras Hindu University (1991) Dr. D.V. Singh in association with international collaborators has successfully shown the clonal relationships between clinical and environmental isolates of V. cholerae indicating aquatic environment serve as a reservoir and transmission of the disease cholera. His group is the first to report occurrence of SXT ICE, dfr18, sulII, strAB and aadA5 genes in environmental V. cholerae O1, and non-O1, and non-O139 strains isolated before 1992 from Varanasi, India, and that showed sequence homology with other bacterial species, suggesting acquisition of SXT ICEs and antibiotic resistance genes occurred from other bacteria. His observation showing loss of the complete and/or partial loss of phage array arranged in tandem lead to understanding of emergence and evolution of variant of V. cholerae strains. Dr. Singh has developed number of multiplex PCRs for rapid detection of virulence genes, serogroups, SXT and antibiotic resistance genes. While working on staphylococcus, he developed multiplex PCR for rapid detection of antibiotic, cadmium/zinc and antiseptic resistance in PVL-positive and -negative S. aureus and CoNS. He found that multi-drug resistant S haemolyticus strains produced biofilm and matrix belongs mostly to eDNA and/or protein. Dr. Singh has 72 publications in international and national ISI Journals – many in collaboration with external scientists.
Research Interest
Understanding the role of genetic element in eDNA release and biofilm development in Staphylococci, ICP1- phage and its role in rugosity and biofilm formation in V. cholerae O1
Publications
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Bhotra Tilothama, Das Moon Moon, Pal BB and Singh DV (2016) Genomic profile of antibiotic resistant, classical ctxB positive Vibrio cholerae O1 biotype El Tor isolated in 2003 and 2005 from Puri, India: a retrospective study. Indian Journal of Medical Microbiology 34(4): 462-470.
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Jha G, Sahu PK, Panda S, Singh DV, Patole S, Mohapatra H and Sarkar M (2017) Synthesis, phytophysical studies on some anthracene based ionic liquids and their application as biofilm inhibitors. Chemistry Select 2(8): 2426-2432.
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Jena Smrutiti, Panda Sasmita, Nayak Kinshuk and Singh DV (2017) Identification of major sequence types among multidrug-resistant Staphylococcus epidermidis strains isolated from infected eyes and healthy conjunctiva. Frontiers in Microbiology 8: 1430.
