Subhasree Roy Choudhury
Scientist B
Department of Science and Technology
Institute of Nanotechnology
India
Biography
Educational Qualification: 2002-2007 Ph.D. from University of Calcutta, India (Subject: Physiology; awarded 2009) SLET 2002 and GATE 2002 Qualified 2001M.Sc. from University of Calcutta, India (Subject: Physiology). 1999 B.Sc. from University of Calcutta, India (Subject: Physiology) (Honors), Chemistry, Zoology. Positions Held :: 2012-2014: Post Doctoral Fellow, The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, QLD 4102, Australia. 2010-2011: Post Doctoral Fellow, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. 2008-2010: Post Doctoral Fellow, Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC 29209, USA. 2007: Post Doctoral Fellow, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. Awards :: Awarded Gold Medal by University of Calcutta for securing the 1st Class 1st rank in M.Sc Physiology in 2001. Awarded with Dr. D.N. Mallick Memorial Gold Medal by the Physiological Society of India for securing the 1st Class 1st rank in M.Sc Physiology in 2001. Awarded with Prof. A. K. Mukherjee Memorial Cup by the 6th Annual Scientific Meet Committee, Calcutta in B.Sc examination in Physiology in 1999. Awarded National Scholarship by the West Bengal Board of Secondary Education in Madhyamik examination in 1994. Awarded Junior Research Fellowship and Senior Research Fellowship by UGC.
Research Interest
Development of target specific nanotherapeutics for epigenetic regulation of cancer. Chemoprevention and mechanism of action of drug/siRNA loaded nanoparticle mediated therapy for leukemia, neuroblastoma and glioblastoma. New drug development from natural products and combination therapy against cancer. Development and application of high-throughput functional gene-based screening for cancer. Multiple retrovirus and lentivirus mediated gene delivery for target validation and functional implication in cancer.
Publications
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• Choudhury SR, Aparna Gomes, Antony Gomes, Jiban K. Dattagupta and Udayaditya Sen (2006) Purification, crystallization and preliminary X-ray structural studies of a 7.2 kDa cytotoxin isolated from the venom of Daboia russelli russelli of the Viperidae family. Acta Cryst. F62, 292–294. PMID: 16511326. .• B.Bishayi, S Roy Chowdhury, S.Ghose & M.Sengupta (2002) Hepatoprotective and Immunomodulatory properties Of Tinospora cordifolia in CCL4 intoxicated mature albino rats. The Journal Of Toxicological Science, 27(3), 139-146. PMID: 12238138.
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• A Gomes, Choudhury SR, A Saha, R Mishra, B Giri, AK Biswas, A Debnath, A Gomes (2007) A heat stable protein toxin (drCT-I) from the Indian Viper (Daboia russelli russelli) venom having antiproliferative, cytotoxic and apoptotic activities. Toxicon, 49(1), 46-56. PMID: 17055549.
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• Nishant Mohan, Surajit Karmakar, Choudhury SR, Naren L. Banik, and Swapan K. Ray (2009) Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Brain Res 1283:155-166. PMID: 19505441.
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• Karmakar S, Davis KA, Choudhury SR, Deeconda A, Banik NL, Ray SK (2009) Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. BBRC 388:705-710. PMID: 19695221.
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• Karmakar S, Choudhury SR, Banik NL, Ray SK (2009) Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. Neuroscience 163:286-295. PMID: 19540315.
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• Karmakar S, Choudhury SR, Banik NL, Ray SK (2010) Activation of Multiple Molecular Mechanisms for Increasing Apoptosis in Human Glioblastoma T98G Xenograft. J Cancer Sci Ther 2: 107-113. PMID: 21666767.
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• Choudhury SR, Karmakar S, Banik NL, Ray SK (2010) Down regulation of angiogenic and survival factors increased apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification. Investigational New Drugs 28:812-24. PMID: 19777160.
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• Karmakar S, Choudhury SR, Banik NL and Ray SK (2011) Molecular Mechanisms of the Anti-cancer Action of Garlic Compounds in Neuroblastoma cells. AntiCancer Agents in Medicinal Chemistry 11(4):398-407. PMID: 21521157.
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• Karmakar S, Choudhury SR, Banik NL, Ray SK (2011) Induction of Mitochondrial Pathways and Endoplasmic Reticulum Stress for Increasing Apoptosis in Ectopic and Orthotopic Neuroblastoma Xenografts. J Cancer Ther, 2, 77-90. PMID:22468231
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• Karmakar S, Choudhury SR, Banik NL, Ray SK (2011) N-(4-Hydroxyphenyl) Retinamide Potentiated Anti-Tumor Efficacy of Genistein in Human Ewing’s Sarcoma Xenografts. World J Oncol 2:53-63. PMID:21822457.
