Surajit Karmakar
Associate Professor
Department of Science and Technology
Institute of Nanotechnology
India
Biography
Educational background:: 1997: BSc from University of Calcutta, India Subject: Physiology (Honors), Zoology, Chemistry. 1999: MSc from University of Calcutta, India Subject: Physiology. 2003: PhD from University of Calcutta, India Subject: Physiology. Positions held:: ♦ Post Doctoral Fellow at The Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia. 2012-2014 ♦ Research Associate at Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. 2010-2011 ♦ Postdoctoral fellow at Department of Pathology, Microbiology and Immunology and Chemical Engineering, University of South Carolina, Columbia, SC 29209, USA. 2008-2010 ♦ Postdoctoral fellow at Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. Employment Period: 2004-2007. Awards:: ♦ New Staff Development Grant: University of Queensland, 2013 ♦ Young Investigator Award, American Society for Neurochemistry, 2005 ♦ Senior Research Fellow, ICMR, New Delhi, India, 2002-2004
Research Interest
Development of cancer nano-therapeutics including screening of peptide and small molecule combinatorial therapy, siRNA delivery and peptide-mediated cancer therapy by targeting mitochondrial metabolism. Understanding molecular mechanisms to overcome resistance to chemotherapy, target validation, signal transduction in membrane proteins and nanoparticles endocytotic cascade. Receptor and ion channel regulation on cell membrane organization, endosomal function and escape.
Publications
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♦ Karmakar S, Banik NL, Patel SJ, and Ray SK (2007) 5-Aminolevulinic acid-based photodynamic therapy suppressed survival factors and activated proteases for apoptosis in human malignant glioblastoma U87MG cells. Neurosci Lett 415:242-247. PMID: 17335970.
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♦ Karmakar S, Banik NL, Patel SJ, and Ray SK (2007) Garlic compounds induce calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis 12:671-684. PMID: 17219050.
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♦ Karmakar S, Banik NL, Patel SJ, Ray SK (2007) Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice. Apoptosis 12:2077-2087. PMID: 17701358.
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♦ Karmakar S, Banik NL, Ray SK (2007) Curcumin Suppressed Anti-apoptotic Signals and Activated Cysteine Proteases for Apoptosis in Human Malignant Glioblastoma U87MG Cells. Neurochem Res 32:2103-2113. PMID: 17562168.
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♦ Karmakar S, Banik NL, Ray SK (2007) Molecular Mechanism of Inositol Hexaphosphate-mediated Apoptosis in Human Malignant Glioblastoma T98G Cells. Neurochem Res 32:2094-2102. PMID: 17616815.
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♦ Karmakar S, Foster Olive M, Banik NL, Ray SK (2007) Intracranial Stereotaxic Cannulation for Development of Orthotopic Glioblastoma Allograft in Sprague-Dawley Rats and Histoimmunopathological Characterization of the Brain Tumor. Neurochem Res 32:2235-2242. PMID: 17701349.
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♦ Karmakar S, Banik NL, Ray SK (2008) Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer 112: 596-607. PMID: 18098270.
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♦ Karmakar S, Choudhury SR, Banik NL, Ray SK (2009) Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. Neuroscience 163:286-295. PMID: 19540315.
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♦ Karmakar S, Davis KA, Choudhury SR, Deeconda A, Banik NL, Ray SK (2009) Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. BBRC 388:705-710. PMID: 19695221.
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♦ Mohan N, Karmakar S, Choudhury SR, Banik NL, Ray SK (2009) Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Brain Res 1283:155-166. PMID: 19505441.
