Saheem Ahmad

Biography

His research team primarily focuses in immunology, biochemistry and cell biology of rare non-enzymatic glycation reaction. The glycation has severe pathophysiological significance in diabetes, atherosclerosis, cancer and neurological disorders. The role of intracellular glycation in cancer state of the disease is very rare and uncommon and is a new target for the prevention of cancer. He is also working on the AGEs-RAGEs interaction (signaling) which activates several pathways including NF-B, IFN- and IL-6 and results in the generation of reactive oxygen species.He lead multi-disciplinary team, working in the field of disease mechanisms - particularly in the study of damage to the proteome by glycation, oxidation and nitration. Major themes of his research are (i) Proteomics of protein damage, Innovative analytical techniques to study protein glycation, oxidation and nitration in ageing and disease. (ii) Dysfunctional lipoprotein metabolism - studying damage to lipoproteins in obesity, diabetes and ageing and risk of atherosclerosis. (iii) Protein damage in arthritis, Biomarker discovery for early-stage diagnosis. (iv) Glycation of intracellular proteins in cancer initiation and progression. (v) A novel nanoconjugation approach to stop the menace of the glycation reaction.

Research Interest

Biochemistry and Intermediary metabolism, Free Radical Biochemistry, Biophysical Techniques, Enzymology, Immunology