Suman Kumar Dhar
Assistant Professor
Special Centre for Molecular Medicine
Jawaharlal Nehru University
India
Biography
His laboratory in JNU is actively engaged in studying the unique characteristics of DNA replication and cell cycle regulation in two medica lly important pathogens, Plasmodium falciparum and Helicobacter pylori . Both these pathogens are extremely important although poorly understood from the basic biology point. Not a single effective vaccine is available for either of these pathogens. There are reports of drug resi stant strains too. Our aim is to find the key regulators in DNA rep lication processes so that we can identify potential targets for therapy. The DNA replicat ion process offers various important and interesting targets for new inhibitors deve lopment. Understanding the mechanism of initiation of DNA replication in P. falciparum and H. pylori will be useful in finding new targets for screening new antibiotics to er adicate these pathogens. We have already identified two such targets (PfGyrase for P. falciparum and HpDnaB helicase for H. pylori ).
Research Interest
Bacterial/Parasite/Mammalian DNA Replic ation and cell cycle regulation
Publications
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Dana S, Prusty D, Dhayal D, Gupta MK, Dar A, Sen S, Mukhopadhyay P, Adak T, Dhar SK. (2014) The potent Anti-malarial activity of Acriflavine in vitro and in vivo . ACS Chem Biol. 2014 Aug 4. [Epub ahead of print]
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Srivastava S, Bhowmick K, Chatterjee S, Basha J, Kundu TK, Dhar SK. (2014) Histone H3K9 acetylation level modulat es gene expression and may affect parasite growth in human malaria parasite Plasmodium falciparum . FEBS J. Sept 22. [Epub ahead of print
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Narayanaswamy N, Kumar M, Das S, Sharma R, Samanta PK, Pati SK, Dhar SK, Kundu TK, Govindaraju T (2014) . A Thiazole Coumarin (TC) Turn-On Fluorescence Probe for AT-Base Pair Dete ction and Multipurpose Applications in Different Biological Systems. Sci Rep. 4:6476.
