Santasabuj Das

Biography

 Dr. Santasabuj Das is currently appointed as Scientist D at National Institute of Cholera and Enteric Diseases (NICED), Kolkata. He is also in-charge of the Biomedical Informatics Center of ICMR at NICED and the Biosafety Officer of the institute. Dr Das graduated in medical sciences (MBBS) in 1989 from the University of Calcutta and completed post-graduation (MD, General medicine) in 1996 from the same university. His post-doctoral training includes senior residency (clinical) at the Department of Clinical Immunology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow (1998) and post-doctoral fellowships at National Center for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India (1998-2000); Kimmel Cancer Centre, Thomas Jefferson University, Philadelphia, PA, USA and Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston, MA, USA. During the early part of his research career, Dr Das worked on the role of Notch signaling in cervical carcinogenesis and transcriptional regulation of MHC Class II molecules. Susequently, he studied the role of Tpl2, an upstream MAPKinase, in the pro-inflammatory cytokine (TNF-a and IL-1b)-induced signal transduction pathways. Dr Das joined NICED in January, 2005 and initiated research on several aspects of the mucosal innate immune responses. His group is studying the regulation of cationic antimicrobial peptide release from the intestinal epithelial cells by enteric pathogens and host gene expression by bacterial motility protein flagellin. Studies to identify new virulence factors of Salmonella typhi and to explore the role of microRNAs in the pathogenesis of hepatitis B and HIV-1 infection are also underway. Dr. Das has 2 PhD students at present and he is the principal investigator of 4 extramural projects, 2 each from the Indian and international funding agencies. He has 5 publications in reputed international journals.

Research Interest

 Molecular Biology, immunology