Bichitra K. Biswal

Biography

M. Sc. Utkal University, Bhubaneshwar, India Ph. D. Molecular Biophysics Unit, IISc, Bangalore, India Postdoctoral Research Dept. of Biochemistry, University of Alberta, Canada

Research Interest

Mycobacterium tuberculosis (Mtb), the organism that causes tuberculosis (TB) in humans, starved of histidine (His) fails to grow/multiply. Primarily in the context of designing new anti-TB compounds, a major project, deciphering the structural and biochemical aspects of enzymes of His biosynthesis pathway, is being pursued. Such studies enable to unravel the molecular mechanisms underlying their action and design enzyme specific inhibitors through a structure-based approach. In another project, we focus on understanding how Mtb membrane associated proteases modulate host factors.