Raghu Pullakhandam
Scientist
Molecular Biology
National Institute of Nutrition
India
Biography
His research deals with understanding the molecular mechanisms of nutrient absorption/interactions and their modulation by other dietary components for providing useful means of developing food based approaches for alleviating micronutrient malnutrition. He is part of the research team that is studying the mechanism of absorption, interactions and bioavailability of iron, zinc and pro-vitamin A carotenoids. He is also involved in characterizing the iron absorption enhancing components from milk, meat, poultry and other traditional plant sources with known Hematinic activity. He specializes in using in vitro approaches to simulate digestion and study the absorption, metabolism, and transepithelial transport of nutrients using cell culture models.
Research Interest
molecular mechanisms of nutrient absorption/interactions, mechanism of absorption, interactions and bioavailability of iron, zinc and pro-vitamin A carotenoids.
Publications
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Raghu P, KM Nair, S Kasula, S Kilari, Thippande TG. Ferric reductase activity of low molecular weight human milk fraction is associated with enhanced iron solubility and uptake in caco-2 cells. (2008), Biochem. Biophys. Res. Comm. Vol 374:369-372
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Sreenivasulu K, Raghu P, Ravinder P and Nair KM. Effect of dietary ligands and food matrices on zinc uptake in caco-2 cells: Implications in assessing zinc bioavailability (2008), Journal of Agr. Food Chem. Vol 56: 10967-10972.
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Raghu P, Srinivas PNBS, Nair KM, Reddy GB. Binding and stabilization of Transthyretin by Curcumin (March 2009) Archives of Biochemistry and Biophysics, In press.
