Prasenjit Manna

Biography

Dr. Manna has a successful track record comprising experience, commitment, and high impact publications in understanding basic molecular mechanisms, conducting studies with diabetic animals and drugs as well as environmental toxin-induced organ pathophysiology. Dr. Manna has published 64 articles in peer-reviewed journals and has an h-index of 26 (Web of Science, as of May2015). Dr. Manna has years of experience in research on streptozotocin-induced type 1 diabetic animal studies. Dr. Manna’s work suggested the beneficial role of a bioactive natural product against streptozotocin-induced diabetes and its associated pathophysiology in rats. In addition, he has also investigated the mechanism of environmentally exposed nanostructure-induced organ pathophysiology. He haslong experience in isolation and characterization of bio-active molecules (protein, small organic molecules) from traditional Indian medicinal plants. During his postdoctoral fellowship in the lab of Dr. Jain since 2010, Dr. Manna has worked on the role of hydrogen sulfide and glutathione in mediating the effect of Lcysteine and vitamin D in insulin signaling pathways using monocyte, 3T3L1 adipocyte, C2C12 myotube, and L6 myotube cell culture models. Dr. Manna’s recent studies have investigated the role of membrane-bound phospho lipids in high glucose-induced impaired glucose metabolism, vascular inflammation, and endothelial cell dysfunction.

Research Interest

The long term research goal is to discover a relatively low-cost dietary supplement (vitamins, minerals, micronutrients etc) that could be used as an adjuvant therapy for the prevention of impaired glucose metabolism in type 2 diabetes.