Dr. Amit Kumar Singh
Assistant Professor
drug discovery
Sharda University
India
Biography
My area of research is structural and functional studies of target proteins in order to understand their biological functions and subsequent functional implication. I am particularly interested in purification, characterization, crystallization and structural studies of proteins through X-ray crystallography in combination with wide range of biophysical techniques to investigate the structural and functional relationship of targeted proteins. I am also interested in the structural and function studies of mammalian heme peroxidases and their role in breast carcinogenesis and hyperthyroidism. I am also interested in characterizing and determining the structures of potential therapeutic and antimicrobial proteins from various natural sources.
Research Interest
Protein Structure Biology and Drug Discovery
Publications
-
Singh, A.K., Singh, N., Sinha, M., Singh, S.B., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. and Singh, T.P. (2009) Structural evidence of substrate specificity in mammalian peroxidases: structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4 Ã… resolution: J. Biol. Chem., 284, 14849-14856.
-
Singh, A.K., Singh, N., Sharma, S., Shin, K., Takase, M., Kaur, P., Srinivasan, A. and Singh, T.P. (2009) Inhibition of lactoperoxidase by its own catalytic product: crystal structure of the hypothiocyanate-inhibited bovine lactoperoxidase at 2.3 Ã… resolution: Biophys. J., 96, 646-654.3. Sheikh, I.A.,
-
Singh, A.K., Singh, N., Sharma, S., Singh, S.B., Kaur, P., Bhushan, A., Srinivasan, A. and Singh, T.P. (2008) Crystal structure of lactoperoxidase at 2.4 Ã… resolution: J. Mol. Biol., 376, 1060-1075.
