Jhimli Dasgupta

Biography

M.Sc (Chemistry), Ph.D (Structural Biology)

Research Interest

1. Structural and functional insights of molecular motors such as bacterial enhancer binding protein (bEBPs): (a) Structural and functional aspects of AAA+ ATPase FlrC and its cognate kinase FlrB of Vibrio cholerae that control flagellar synthesis and biofolm formation. (b) FlrA, the master transcription regulator of Vibrio cholerae flagellar synthesis: Structural insights, oligomerisation, functional implications and regulation by the second messenger c-di-GMP. 2. ‘Trojan horse mechanism’ of drug delivery through ABC transporters: 2 (a) Structural and functional insights into the periplasmic Fe(III) and heme binding proteins FhuC and HutB of Vibrio cholerae to unravel the mechanism of iron uptake in survival strategy. (b) Unraveling the molecular mechanism of vitamin B12 and norspermidine uptake by Vibrio cholerae periplasmic binding proteins BtuF and NspS. 3. Understanding the role of multiple copies of chemotaxis response regulators (CheYs) and their interactions with kinase CheA to control flagellar motion of Vibrio cholerae