Ankona Datta
Assistant Professor
Department of Chemical Sciences
Tata Institute of Fundamental Research
India
Biography
Dr. Ankona Datta is an Assistant Professor at the Department of Chemical Sciences , TIFR. Her work focuses on organic and inorganic chemistry with an emphasis on chemical biology and molecular imaging. We propose to use a range of tools pertaining to the aforementioned fields to explore new frontiers in disease detection and to understand the fundamental molecular mechanisms underlying disease. Specifically, we are interested in designing and applying novel chemical probes and sensors for imaging disease markers both in vitro and in live biological samples. A few systems of interest include imaging metal ion trafficking and its implications in neurodegenerative diseases, apoptotic signals in cancer and peroxidase activity up-regulation in atherosclerosis. In developing the imaging probes we will design and synthesize small molecule organics, metal complexes, nano-conjugates and modified proteins each with a targeted application. These probes will be characterized and evaluated by a series of spectroscopic and imaging techniques such as NMR, EPR, GC, LC, ICP-MS, X-ray crystallography, optical and magnetic resonance imaging. For more details on specific projects see the group webpage.
Research Interest
Synthetic chemistry, Chemical biology and Molecular imaging.
Publications
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Datta A, Quintavalla MSand,Groves JT (2007) nKinetic Selectivity in the N-Alkylation of 2-Pyridyl Porphyrins: A Facile Approach to the aabb Scaffold,J. Org. Chem.5 pp: 1818-1821
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Eric JW, Datta A, Jocher CJ, Raymond KN (2008) High-Relaxivity MRI Contrast Agents: Where Coordination Chemistry Meets Medical Imaging, Angew. Chem. Int. Edit.45 pp: 8568-8580.
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Datta A, Raymond KN (2009) Gd-Hydroxypyridinone (HOPO)-Based High-Relaxivity Magnetic Resonance Imaging (MRI) Contrast Agents, Accounts Chem. Res.7 pp: 938-947.
