Gotam K Jarori
Professor
Department of Biological Sciences
Tata Institute of Fundamental Research
India
Biography
Dr. Gotam K Jarori is a Professor at School of Biological Sciences , TIFR. His work focuses on Living cells a complex chemical machine where almost all functions are performed by proteins. Understanding the biochemical and biological function(s) of these molecules and correlating these to their structure, is the prime objective of our research. Currently we are investigating some of the proteins from P. falciparum with an objective to understand basic parasite biology and to identify novel drug and vaccine targets against malaria. One such protein is 'enolase', a glycolytic enzyme.His studies show that this protein is present on cell surface, nucleus, cytosol and associate with food vacuole and cytoskeletal structures. His efforts at present are focused on understanding the novel biological functions that enolase may have in parasite nucleus, food vacuole and cell membrane.
Research Interest
Structure-activity relationship (SAR) in proteins .
Publications
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Vora HK, Shaik FR, Pal-Bhowmick I, Mout R, Jarori GK (2009) Effect of deletion of a plant like pentapeptide insert on kinetic, structural and immunological properties of Enolase from Plasmodium falciparum. Archives of Biochemistry and Biophysics 485: 128.
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Das S, Shevade S, LaCount DJ, Jarori GK (2011) Plasmodium falciparum enolase complements yeast enolase functions and associates with the parasite food vacuole. Molecular and Biochemical Parasitology 179: 8.
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Mout R, Xu ZD, Wolf AK, Davisson VJ, Jarori GK (2012) Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii. Malaria Journal 11: 54.
