Maithreyi Narasimha
Associate Professor
Department of Biological Sciences
Tata Institute of Fundamental Research
India
Biography
Dr. Maithreyi Narasimha is an assoicate professor in the School of biological sciences , Her work is based on Cells in tissues exhibit stochastic and collective behaviors and seem capable of "self-organization". What drives distinct cell behaviours? How do cells sense their neighborhood and adapt to perturbations (like cell division, death, wounds) they encounter? What rules do they follow when doing so? Cells communicate using a combination of chemical and physical cues and "cell junctions" containing adhesion molecules can transduce both. How do contact or chemicals mediate changes in cell behavior? Do they work alone or together? We study design principles of cellular reorganization accompanying Drosophila morphogenesis and mouse embryonic stem (ES) cell differentiation using a combination of genetics, live confocal microscopy, biophysical perturbations, computational and theoretical approaches facilitated by quantitative analysis and collaborations with theoretical and experimental physicists.
Research Interest
Cell adhesion, Epithelial morphogenesis and Cellular reorganization.
Publications
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Meghana C, Hameed FM, Ramdas N, Rao M, Shivashankar GV, Narasimha M (2011) Integrin adhesion drives the emergent polarization of active stresses to pattern the dynamics of delamination. Proceedings of the National Academy of Sciences USA 108: 9107.
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Saravanan S, Meghana C, Narasimha M (2013) Local, cell non-autonomous feedback regulation of myosin dynamics patterns transitions in cell behaviour; a role for tension and geometry? Molecular Biology of the Cell 24: 2350.
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Muliyil S, Narasimha M (2014) Mitochondrial ROS Regulates Cytoskeletal and Mitochondrial Remodeling to Tune Cell and Tissue Dynamics in a Model for Wound Healing. Developmental Cell 28: 239.
